I build mathematical and statistical models to address a variety of interesting problems mostly related the biology of infectious diseases. My principle focus has been the development of models to extract information from pathogen sequence information. For example, I have developed statistical models to detect the presence of recombination in pathogen sequences. Using these models to identify the location of recombination crossover events, has permitted the identification of possible hotspots of recombination. Another model uses sequence information to identify the historical location of selection events. A selection event associated with the formation of distinct HIV genotypes may ultimately help explain differences in viral pathogenecity.
Dr. Karin S Dorman
Area of Expertise:
M.S., Mathematics and Biology, Indiana University, 1994
Ph.D., Biomathematics, University of California, Los Angeles, 2001